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PRINCIAL INVESTIGATORAssist. Prof. Irena Arandjelović (former Živanović)

Management and integrity of the project design. Realization of research activities. Conducting and reporting of the project results. Managing, monitoring, and ensuring of collaborative research.

PHONE NUMBER
+381 11 364 33 65
irena.arandjelovic@med.bg.ac.rs

CAREER IN NUMBERS

12

YEARS OF EXPERIENCE

14

SCIENTIFIC PUBLICATIONS

304

CITATION NUMBER

6

HIRSCH INDEX

SKILLSAbout Assist. Prof Irena Arandjelović

Educational researcher, competent in microbiological theory and methods, collecting, handling, analyzing, evaluating, and reporting data relative to the type and scope of the research, performing molecular and bioinformatics pipelines independently, several existing international research collaborations.

Understanding pathogens’ behavior means understanding their evolution.
Assist. Prof. Irena Arandjelović (former Živanović)
PRINCIAL INVESTIGATOR

ACHIEVEMENTSBiography

Dr. Arandjelović is a Specialist in Medical Microbiology and Ph.D. in Molecular Medicine. She is a member of the National Reference Laboratory for tuberculosis, and co-author of the national „Guide for microbiological diagnosis of tuberculosis“ (3rd edition, Belgrade, 2015). Research activities of Dr. Arandjelović are focused on mycobacteria, primarily on the evolution of multidrug-resistant (MDR) M. tuberculosis strains. From 2010 to 2015, she was engaged in several projects funded by the Ministry of Health of the Republic of Serbia and supported by the Global Fund to Fight AIDS, Tuberculosis and Malaria. She is engaged in the project „Bacteria resistant to antibiotics in Serbia: phenotypic and genotypic characterization“ funded by the Ministry of Education, Science and Technological Development of the Republic of Serbia from 2011. Dr. Arandjelovic is collaborator of the Comprehensive Resistance Prediction for Tuberculosis: an International Consortium (CRyPTIC) from 2017. Within CRyPTIC project, funded by the Bill & Melinda Gates Foundation and Wellcome Trust/MRC Newton Fund, she is a contributor of the whole genome sequencing data on MDR M. tuberculosis strains isolated in Serbia for bioinformatic and machine learning analyses aimed at predicting susceptibility and resistance of M. tuberculosis to antituberculosis drugs.

ASSOCIATIONS AND MEMBERSHIPS

Serbian Medical Society, Serbian Medical Chamber, Serbian Society for Microbiology, Federation of European Microbiological Societies (FEMS), National Reference Laboratory for tuberculosis

SELECTED PUBLICATIONS
  1. Walker TM, Miotto P, Köser CU, Fowler PW, Knaggs J, Iqbal Z, Hunt M, Chindelevitch L, Farhat M, Cirillo DM, Comas I, Posey J, Omar SV, Peto TE, Suresh A, Uplekar S, Laurent S, Colman RE, Nathanson CM, Zignol M, Walker AS; CRyPTIC Consortium; Seq&Treat Consortium (Arandjelovic I), Crook DW, Ismail N, Rodwell TC. The 2021 WHO catalogue of Mycobacterium tuberculosis complex mutations associated with drug resistance: A genotypic analysis. Lancet Microbe. 2022 Apr;3(4):e265-e273.
  2. Yang Y, Walker TM, Kouchaki S, Wang C, Peto TEA, Crook DW, CRYPTIC Consortium (Arandjelović I), Clifton DA. An end-to-end heterogeneous graph attention network for Mycobacterium tuberculosis drug-resistance prediction. Brief Bioinform. 2021 Aug 20; bbab299; link
  3. Assaleh MH, Bjelogrlic SK, Prainovic N, Cvijetic I, Bozic A, Arandjelovic I, Vukovic D, Marinkovic A.
    Antimycobacterial and anticancer activity of newly designed cinnamic acid hydrazides with favorable toxicity profile. Arabian Journal of Chemistry. 2021 October 30; 15: 103532; link
  4. Wilson DJ, CRyPTIC Consortium. GenomegaMap: Within-species genome-wide dN/dS estimation from over 10,000 genomes. Mol Biol Evol 2020; 37: 2450-60; DOI: 10.1093/molbev/msaa069.
  5. Hunt M, Bradley P, Lapierre SG, Heys S, Thomsit M, Hall MB, Malone KM, Wintringer P, Walker TM, Cirillo DM, Comas I, Farhat MR, Fowler P, Gardy J, Ismail N, Kohl TA, Mathys V, Merker M, Niemann S, Omar SV, Sintchenko V, Smith G, van Soolingen D, Supply P, Tahseen S, Wilcox M, Arandjelovic I, Peto TEA, Crook DW, Iqbal Z. Antibiotic resistance prediction for Mycobacterium tuberculosis from genome sequence data with Mykrobe. Wellcome Open Res 2019; 4: 191. DOI: 10.12688/wellcomeopenres.15603.1.
  6. Arandjelović I, Merker M, Richter E, Kohl TA, Savić B, Soldatović I, Wirth T, Vuković D, Niemann S. Longitudinal outbreak of multidrug-resistant tuberculosis in a hospital setting, Serbia. Emerg Infect Dis 2019; 25: 555-58; DOI: 3201/eid2503.181220.
  7. Yang Y, Walker TM, Walker AS, Wilson DJ, Peto TEA, Crook DW, Shamout F, CRyPTIC consortium, Zhu T, Clifton DA. DeepAMR for predicting co-occurrent resistance of Mycobacterium tuberculosis. Bioinformatics 2019; 35: 3240-49; DOI: 10.1093/bioinformatics/btz067.
  8. Kouchaki S, Yang Y, Walker TM, Walker S, Wilson DJ, Peto TEA, Crook DW, CRyPTIC Consortium, Clifton DA. Application of machine learning techniques to tuberculosis drug resistance analysis. Bioinformatics 2019; 35: 2276-82; DOI: 0.1093/bioinformatics/bty949.
  9. Dakić I, Arandjelović I, Savić B, Jovanović S, Tošić M, Kurucin T, Vuković D. Pulmonary isolation and clinical relevance of nontuberculous mycobacteria during nationwide survey in Serbia, 2010-2015. PloS One 2018; 13: e0207751.
  10. CRyPTIC Consortium and the 100,000 Genomes Project, Allix-Beguec C, Arandjelovic I, Bi L, Beckert P, Bonnet M, Bradley P, Cabibbe A, Cancino-Munoz I, Caulfield MJ, Chaiprasert A, Cirillo D, Clifton D, Comas I, Crook DW, De Filippo MR, de Neeling H, Diel R, Drobniewski FA, Faksri K, Farhat MR, Fleming J, Fowler P, Fowler TA, Gao Q, Gardy J, Gascoyne-Binzi D, Gibertoni Cruz A, Gil-Brusola A, Golubchik T, Gonzalo X, Grandjean L, He G, Guthrie JL, Hoosdally S, Hunt M, Iqbal Z, Ismail N, Johnston J, Masood Khanzada F, Chuen Khor C, Kohl TA, Kong C, Lipworth S, Liu Q, Maphalala G, Martinez E, Mathys V, Merker M, Miotto P, Mistry N, Moore D, Murray M, Niemann S, Twee-Hee Ong R, A Peto TE, Posey JE, Prammananan T, Pym A, Rodrigues C, Rodrigues M, Rodwell T, Rossolini GM, Sanchez Padilla E, Schito M, Shen X, Shendure J, Sintchenko V, Sloutsky A, Smith EG, Snyder M, Soetaert K, Starks AM, Supply P, Suriyapol P, Tahseen S, Tang P, Teo YY, Nguyen Thuy Thuong T, Thwaites G, Tortoli E, Omar SV, van Soolingen D, Walker S, Walker TM, Wilcox M, Wilson DJ, Wyllie D, Yang Y, Zhang H, Zhao Y, Zhu B. Prediction of susceptibility to first-line tuberculosis drugs by DNA sequencing. N Engl J Med 2018; 379:1403-15; DOI: 1056/NEJMoa1800474.
  11. Šmitran A, Vuković D, Opavski N, Gajić I, Marinković J, Božić Lj, Živanović I, Kekić D, Popović S, Ranin L. Influence of subinhibitory antibiotic concentration on Streptococcus pyogenesadherence and biofilm production. Acta Microbiol Immunol Hung 2018;65:229-40.
  12. Miletić M, Vuković D, Živanović I, Dakić I, Soldatović I, Maletić D, Lazović S, Malović G, Petrović Z, Puač N. Inhibition of methicillin resistant Staphylococcus aureus by a plasma needle. Cent Eur J Phys 2014;12:160-7.
  13. Živanović I, Vuković D, Dakić I, Savić B. Species of Mycobacterium tuberculosis complex and nontuberculous mycobacteria identified in respiratory specimens from Serbia. Arch Biol Sci 2014;66:553-61.
  14. Živanović I, Vuković D, Dakić I, Stefanović G, Savić B. Detection of extensively drug-resistant Mycobacterium tuberculosis strains by the GenoTypeMTBDRsl assay in Serbia. Arch Biol Sci 2012;64:1311-18.
INTERNATIONAL ENGAGEMENT

2019 –           collaboration with Department of Applied Microbiology, Institute of Microbiology, Faculty of Biology, University of Warsaw (Dr. Tomasz Jagielski); contribution of M. kansasii strains isolated in Serbia for genotyping in order to establish the global prevalence of the newly proposed Mycobacterium species (former M. kansasii subtypes) in the context of patient socio-demographic and clinical data.

2017 –           collaboration with Nuffield Department of Medicine, University of Oxford, Oxford, England (Dr. Timothy Walker); contribution of the WGS data on MDR M. tuberculosis strains from Serbia for the CRyPTIC Consortium.

2015              one month stay in the Molecular and Experimental Mycobacteriology Group, Research Center Borstel, Borstel, Germany (Lab Head Prof. Stefan Niemann) for training and performance of bioinformatic analysis of WGS data on 115 MDR M. tuberculosis strains isolated in Serbia from 2008 to 2014.

2014              three months stay in the Molecular and Experimental Mycobacteriology Group, Research Center Borstel, Borstel, Germany (Lab Head Prof. Stefan Niemann) for training and performance of spoligotyping, MIRU-VNTR and whole genome sequencing for 115 MDR M. tuberculosis strains isolated in Serbia from 2008 to 2014.

GRANTS AND AWARDS

FEMS (Federation of European Microbiology Societies) Research Grant 2013 for research and training on performance of spoligotyping, MIRU-VNTR and whole genome sequencing at the Molecular and Experimental Mycobacteriology Group, Research Center Borstel, Borstel, Germany (3 months).

EDUCATION

2011 – 2018         Specialization in Medical microbiology; Faculty of Medicine, University of Belgrade; an average grade 5.0/5.0

2009 – 2015         Ph.D. studies; module Molecular medicine, Faculty of Medicine, University of Belgrade; title of Ph.D. thesis “Species, phylogenetic lineages and genetic basis of resistance in multidrug-resistant Mycobacterium tuberculosis complex strains isolated in Serbia”; an average grade 10.0/10.0

2000 – 2008         Integrated academic studies of Medicine; Faculty of Medicine, University of Belgrade; an average grade 9.29/10.0